Cisplatin binding protein

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August undefined, 2024

WebThe protein binding rates (PBR) of platinum-containing agents cisplatin (CDDP), carboplatin (CBDCA) and oxaliplatin (L-OHP) have been reported as 98%, 25-50% and 98%, respectively. To investigate the protein-binding properties of albumin with cisplatin, carboplatin and oxaliplatin, inductively coupl … WebJan 14, 1994 · Cisplatin-DNA adducts bind several cellular proteins, including some that enhance survival of the cell by mediating DNA repair and others that hasten its death by conferring sensitivity to the drug. Publication types Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review MeSH terms Animals Apoptosis / drug effects

Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma …

WebFull article: Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy Home All Journals Bioengineered List of Issues Volume 13, Issue 2 Insulin-like growth factor 2 mRNA-bindin .... Bioengineered WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of … small fleet maintenance software

Targeted therapy for cisplatin‐resistant lung cancer via …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). ... belonging to the USP protein family, reacts with the 26S proteasome complex and … WebJun 13, 2005 · Protein binding Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. songs for cats to go to sleep

Cisplatin Binding Sites in Human H-Chain Ferritin

Cisplatin binding to proteins: A structural perspective

WebJun 20, 2024 · Cisplatin [ cis- diamminedichloroplatinum (II) ( cis -DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its … WebCisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus by Umma Habiba 1,2,*, Elora Hossain 3, Aya Yanagawa-Matsuda 4, Abu Faem Mohammad Almas Chowdhury 5, Masumi Tsuda 1,6,7, Asad-uz- Zaman 2, Shinya Tanaka 1,6,7 and Fumihiro Higashino 3,4,* 1 small fleet insurance irelandWebMar 25, 2024 · Given that apoptosis resistance is one of the causes of the cisplatin resistance of tumor cells, our aim was to determine the relationship between RRS1 and cisplatin resistance in breast cancer cells. Here, we report that RRS1 is associated with cisplatin resistance in breast cancer cells. songs for burns night

"WebMay 26, 2024 · Using the fluorescent cisplatin analog BODIPY-cisplatin, two-dimensional gel electrophoresis, and mass spectrometry, we identified the protein binding partners in … " - Cisplatin binding protein

Cisplatin binding protein

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin …

WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6 WebJun 3, 2013 · To identify proteins that bind to cisplatin, we synthesized two different platinum-agarose conjugates, one with two amino groups and another with two chlorides attached to platinum that are available for protein binding, and conducted pull-down assays using cochlear and kidney cells.

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WebC-terminal binding protein‑2 (CtBP2) is a transcriptional co-repressor that is associated with tumorigenesis and tumor progression. It has been reported to predict a poor … WebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic …

WebSep 1, 2024 · Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP contains … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

Web14 hours ago · The EV surface proteins as well as their expression in cells were analyzed with western blots. For the EV surface protein profiling, a coverslip coated with poly-l-lysine (PLL) to bind EVs and casein to reduce the unspecific binding of fluorescently tagged antibodies was used. The coverslip was probed with EVs and subsequently incubated … WebPreviously, we reported that the RNA binding protein with multiple splicing (RBPMS) is a miR-21-3p target gene in cisplatin-resistant ovarian cancer cells . RBPMS—also known as HERMES [ 16 , 17 ]—is a gene located on chromosome 8 position p12 spanning over 230 kb (30,241,924 to 30,430,508 bp) in the human genome [ 18 ].

WebFeb 1, 2016 · Cisplatin owns the most tendency to plasma proteins-so that after a few hours, up to 90% of the drug is bound to protein [19, 20]. Carboplatin possesses the … songs for brushing teeth for kidsWebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … small fleet owner operatorWebCisplatin is a platinum-based drug which acts by binding to DNA by forming intrastrand cross-link conjugate which eventually leads to apoptosis due to the activation of p53, … songs for catholic mass todayWebApr 13, 2024 · HIGHLIGHTS. who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines, in the … songs for business reelsWebThese results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. ... Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and … small fleet maintenance tracking spreadsheetWebMay 15, 2016 · We summarize the structural features of known cisplatin-protein adducts. • Key characteristics of the cisplatin modes of binding to proteins are described. • … songs for celebrationWebMay 26, 2024 · Using the fluorescent cisplatin analog BODIPY-cisplatin, two-dimensional gel electrophoresis, and mass spectrometry, we identified the protein binding partners in A2780 and cisplatin-resistant A2780cis ovarian carcinoma, as well as in HCT-8 and oxaliplatin-resistant HCT-8ox colorectal cell lines. songs for celebrate recovery