Cisplatin-induced nephrotoxicity

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August undefined, 2024

WebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the … Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH ratio signiﬁcantly decreased with cisplatin treatment suggesting that cisplatin induced oxidative stress response in the kidney. GSH/oxidized GSH ratio is known to be an

Identifying cisplatin-induced kidney damage in paediatric …

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebAug 6, 2014 · The use of cisplatin is frequently limited by various significant side effects such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity. After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11]. earn money online by pc gaming

Protective Effect of Magnesium Preloading on Cisplatin-induced ...

WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … WebFeb 15, 2024 · We then examined GSDME cleavage in a cisplatin-induced mouse model of nephrotoxicity and found that cisplatin increased serum creatinine and BUN (Fig. 1 E, F). HE staining exhibited severe... WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … csx children\u0027s investment fund

Cisplatin nephrotoxicity: new insights and therapeutic …

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. Capparaceae Medicine & Life Sciences 100%. Proximal Kidney Tubule Medicine & Life Sciences 50%. Cisplatin Medicine ... csx chief operating officerWebFeb 5, 2014 · Nephrotoxicity caused by cisplatin is a well-known side effect and is dose-limiting toxicity that most commonly manifests as an acute and chronic impairment of renal function in almost all cisplatin-containing regimens. Nephrotoxicity appears to be clinical problem in 28–42% of patients treated with cisplatin in clinical practice ( 1–3 ). earn money online by pc part time

"WebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. … " - Cisplatin-induced nephrotoxicity

Cisplatin-induced nephrotoxicity

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

WebResults: The incidence of nephrotoxicity was 23.7% overall, with 8.1% of patients developing cisplatin-induced nephrotoxicity after the first dose. Patients who … WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk...

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WebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the nephroprotective activity of hydroalchoholic extract of P. americana (HEPA) leaves on cisplatin induced nephrotoxicity in albino wistarrats. WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI.

WebA multivariate analysis indicated that magnesium preloading significantly reduced cisplatin-induced nephrotoxicity throughout the entire period from after the first administration (odds ratio: 0.262, 95% confidence interval: 0.106-0.596 during the first cycle, and odds ratio: 0.234, 95% confidence interval: 0.129-0.414 during all cycles). WebThe aim of this study was to examine the effect of magnesium supplementation on the prevention of cisplatin-induced nephrotoxicity for patients with esophageal and hypopharyngeal cancer. Twenty-three patients with esophageal or hypopharyngeal cancer were studied over 2 weeks. Ten of them received magnesium supplementation and 13 …

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can … Webcisplatin-induced acute nephrotoxicity. The role of oxidant-antioxidant systems in chronic nephrotoxic-ity is uncertain. Reactive nitrogen species have also been studied in …

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WebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. csx chillicothe ohWebFeb 1, 2024 · Abstract Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity. earn money online by pc in paytm earn money online by typing pages in indiaWebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute kidney injury requiring dialysis. earn money online by playing gamesWebCisplatin toxicity arises most characteristically in the kidneys, cochlea, bone marrow, gastrointestinal mucosa and nerves (with altered taste, peripheral neuropathy and encephalopathy). The kidneys are particularly susceptible to cisplatin toxicity, as they are almost exclusively responsible for its excretion. earn money online copy paste jobWebResults: The incidence of nephrotoxicity was 23.7% overall, with 8.1% of patients developing cisplatin-induced nephrotoxicity after the first dose. Patients who developed nephrotoxicity had a higher mean risk prediction score compared to patients who did not have nephrotoxicity (4.0 ± 2.0 versus 2.9 ± 2.1, p = 0.004, respectively). earn money online by typing in pakistanWebCisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in cancer treatment. However, the molecular mechanism of cisplatin-induced nephrotoxicity is currently unclear. Using pharmacological and gene knockout models, we now demonstrate a pathological role for p53 in cisplatin nephrotoxicity. earn money online by typing philippines