WebJun 15, 2005 · In this study, we demonstrate that CCR5 deficiency promotes the development of acute FLF in mice following Con A administration by preventing activated hepatic CD1d-restricted NKT cells (but not conventional T cells) from dying from activation-induced apoptosis. WebJun 15, 2005 · Analysis of hepatic CD1d-tetramer + NKT cells in WT mice during Con A-induced fulminant hepatitis. a, Reduced number of CD1d-tetramer + NKT cells in the liver of Con A-treated WT mice ( n = 4–7); ∗∗, p < 0.01 vs naive mice. b, A representative FACS dot plot depicting the loss of CD1d-tetramer + NKT cells (arrows in upper right quadrant) …

Lack of chemokine receptor CCR5 promotes murine fulminant liver …

WebFulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in … WebFeb 1, 2024 · Fulminant hepatitis was induced by co-injection of 5 μg/kg lipopolysaccharide (LPS) (Escherichia coli, 0111:B4, Sigma, US) and 400 mg/kg D … round 2hal

Critical contribution of liver NKT cells to a murine model of hepatitis …

WebNov 15, 2014 · Fulminant hepatitis (FH) is a rare, but potentially fatal, disease in which the patient’s condition rapidly deteriorates; it can cause hepatic encephalopathy, necrosis of the hepatic parenchyma, coagulopathy, renal failure, and coma. Without supportive management and/or liver transplantation, the mortality is ∼70% ( 1 ). WebFulminant hepatitis is a rare syndrome of rapid (usually within days or weeks), massive necrosis of liver parenchyma and a decrease in liver size (acute yellow atrophy); it … WebFulminant hepatic failure is a dramatic clinical syndrome characterized by massive necrosis of liver cells.1 It is most often caused by hepatitis A virus and hepatitis B virus … strataderm scar therapy gel before and after