The median-effect equation (MEE) of the mass-action law (MAL) was delivered by Chou in 1976 through the derivation of over 300 rate equations of enzyme dynamics, patten analysis, combination analysis, followed by mathematical induction and deduction. The relativity ratio of the fraction affected (fa) vs the fraction unaffected (fu) is equal to the dose (D) vs the median-effect dose (Dm) to the m power, where Dm signifies potency and m signifies … WebDec 1, 2024 · The median-effect equation (MEE) derived from system analysis of the mass-action law (MAL) is the unified general theory of dose-effect pharmacodynamics (PD) and biodynamics (BD), [MAL-PD/BD]. MEE enables the linearization of a …
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WebSep 29, 2015 · Median-effect extrapolations to ≥99% inhibition were experimentally verified using a titre-reduction assay, where CH31 produced a 3-log reduction in viral titre at 10 times its IC 80... WebThe general equation for this model is given in Equation (1), where E is the predicted response of the agent on the system, E0 is the baseline response for a drug concentration of 0, Emax is the maximum response, C is the concentration used for the predicted response E, and EC50 is the concentration for which 50 percent of the maximal response is … green clean antigonish
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WebBased on the median-effect equation of Chou and the combination index (CI) equation of Chou-Talalay, a computer software for automated dose-effect analysis has been developed. This method provides quantitation of synergism (CI < 1) and antagonism (CI > 1) at different dose and effect levels. Therefore, it allows the selection of the best pair ... WebMedian for Even number of Observations. If the dataset is even, then the mean value or average for the middle two numbers is called the median of the given data set. Eg. … WebBased on the Combination index Theorem (CIT) and the Median-Effect Equation and Plot, when the combination (D) 1,2 for (D) 1 and (D) 2 is P/Q, we got : Therefore, substituting, the m and Dm parameters, combination ratio P/Q into the corresponding equations given above, and setting fa=0.01-0.99, the CI values at all effect levels can be simulated as green clean auto wash jacksonville nc