Webb22 dec. 2014 · The mRNA binding protein HuR is over expressed in cancer cells and contributes to disease progression through post-transcriptional regulation of mRNA. The regulation of HuR and how this relates to glioma is the focus of this report. SRC and c-Abl kinases regulate HuR sub-cellular trafficking and influence accumulation in the … Webb7 nov. 2008 · Instead, unstable proteins appear to be rich in amino acids that can be phosphorylated, such as tyrosine and threonine. Indeed, phosphorylation is frequently a …

A widespread family of heat-resistant obscure (Hero) proteins …

Webb20 sep. 2024 · Thus, expanded CGG-repeat tracts cause two forms of genetic instability, one involving localized changes in and around the repeat tract, while the second causes chromosome instability, resulting in loss of all or part of the affected chromosome, which is seen in some carriers of FM alleles. Webb5 dec. 2024 · Protein instability can be beneificial Before discussing the limitations imposed by protein instability, it’s important to understand that low levels of stability are … rubbermaid commercial corn broom

PremPS: Predicting the impact of missense mutations on protein …

WebbCognitive deficits and hyperactivity were also observed in these mouse models, but not autism related social deficits. Our data suggest protein instability, haploinsufficiency … Webb25 feb. 2024 · The accurate prediction of the change in protein fold stability (ΔΔG) upon amino-acid substitution is a central challenge in modern biology, the solution to which … rubbermaid commercial brute tote